Biochem/physiol Actions

MYB proto-oncogene like 2/v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2/B-MYB) protein regulates cell proliferation, differentiation, and DNA repair. It participates in DNA replication in embryonic stem cells. MYBL2 protein can modulate stem cell genes. MYBL2 gene expression is altered in breast, ovarian, liver, colon, rectal, blood, brain, and bladder cancers. MYBL2 affects cell cycle progression and apoptosis in a regulated manner. It serves as a cell cycle modulator in hepatocellular carcinoma (HCC).

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General description

MYB proto-oncogene like 2/v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2/B-MYB) belongs to the MYB family of transcription factors. MYBL2 gene is located on human chromosome 20q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human B-Myb.Immunogen Range: 551-600

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.