Biochem/physiol Actions

In platelets, SEPT8 (septin 8) participates in granula secretion. It also participates in cytokinesis, vesicle trafficking and exocytosis. The protein mitogen-activated protein kinase-activated protein kinase 5 (MK5) phosphorylates and modulates septin 8, which interacts with various synaptic vesicle proteins and may participate in the release of neurotransmitters.

Features and Benefits

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General description

Anti-SEPT8 Antibody detects endogenous levels of total SEPT8 protein.

Septins are cytoskeletal GTPases. SEPT8 (septin 8) belongs to septin family. It is expressed in brain. It is also present in heart, aorta, prostate, testis and ovary. It is located on human chromosome 5q31.

Immunogen

The antiserum was produced against synthesized peptide derived from human SEPT8.Immunogen Range: 170-219

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.