Biochem/physiol Actions

CCNO (cyclin O) is responsible for the differentiation of multiciliated cell. It participates in the cell cycle and DNA repair. CCNO mutations cause congenital mucociliary clearance disorder. It is considered as an important enzyme in base excision repair (BER).

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General description

UNG2 (uracil-DNA glycosylase) is a multifunctional glycosylase,that is located in the nucleus. It is also known as CCNO (cyclin O)and is located on chromosome 5q11. It is present in the apical cytoplasm of multiciliated cells.

Immunogen

a 14 amino acid peptide from near the amino-terminus of human UNG2.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3859.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide