Application

Anti-Human IgA antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Ig α-1 chain C region is a protein encoded by the IGHA1 gene in humans. IgA deficiency (IgAD) is the most common immunodeficiency and it has 2 subclasses, they are IgA1 and IgA2. Its heavy chains are encoded by the α1 and α2 genes. Galactose-deficient IgA1 (GdIgA1) has an important role in the pathogenesis of IgA nephropathy (IgAN). It can act as a useful non-invasive IgAN biomarker. Immunoglobulin A nephropathy (IgAN) is associated with genetic as well as environmental factors and undergalactosylation of IgA1 in the serum may contributor to pathogenesis of IgAN.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

IgA native protein.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.