Application

Anti-Histone H1,1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Histone H1.1 is a protein encoded by the HIST1H1A gene in humans and the gene is expressed in testis and thymus, but not in other human tissues. It is located on chromosome 6(6p21-p22) containing 55 histone genes. ist1 on mouse chromosome 13 contains 51 histone genes. There are 2 different human H1 histones coding genes that are differentiated mainly due to the N- and C-terminal H1 domains, whereas the central part of the protein is highly conserved. Histone H1 is a fundamental chromosomal protein and is associated with the maintenance of higher-ordered chromatin organization. It functions in the compaction of chromatin into higher order structures and its modulation is an important step in the potentiation/depotentiation of chromatin structure for transcription. H1 binds less tightly than other histones to DNA in chromatin and can readily exchange in living cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Immunogen Sequence: GI # 121903, sequence 1-104

Histone H1.1 native protein.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.