D1756-25MG Display Image
D1756-25MG Display Image

Dexamethasone, >=98% (HPLC), powder

Code: D1756-25MG D2-231

Application

Dexamethasone has been used:• in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue • as a component of adipocyte differ...

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£19.53 25MG
List Price

Application

Dexamethasone has been used:• in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue • as a component of adipocyte differentiation medium• for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

25, 100, 500 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

1, 5 g in glass bottle

Reconstitution

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Gene Informationhuman ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)

mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)

rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Quality Level200
storage temp.2-8C
InChI keyUREBDLICKHMUKA-CXSFZGCWSA-N
originatorMerck & Co., Inc., Kenilworth, NJ, U.S.
formpowder
assay98% (HPLC)
coloroff-white
InChI1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
mp262-264 C (lit.)
solubilitymethanol: 25 mg/mL
SMILES stringC[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

Code
Description
Unit Size
List Price
Qty
D1756-100MG
Unit:100MG
List Price: £49.99
Source:List Price
ADD
D1756-500MG
Unit:500MG
List Price: £143.87
Source:List Price
ADD
D1756-1G
Unit:1G
List Price: £214.24
Source:List Price
ADD
D1756-5G
Unit:5G
List Price: £658.46
Source:List Price
ADD
Cas Number50-02-2