D1692-5MG Display Image
D1692-5MG Display Image

GW4869, >=90% (NMR)

Code: D1692-5MG D2-231

Application

GW4869 has been used:• as an inhibitor of neutral sphingomyelinase and exosome biogenesis• to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma...

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£162.78 5MG
List Price

Application

GW4869 has been used:• as an inhibitor of neutral sphingomyelinase and exosome biogenesis• to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production• to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats

Biochem/physiol Actions

A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-a by plasmacytoid dendritic cells (pDCs).

Packaging

5, 25 mg in glass bottle

InChI keyNSFKAZDTKIKLKT-LOLTXFFGSA-N
SMILES stringCl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)C=C/c3ccc(C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
storage conditiondesiccated
storage conditionprotect from light
Quality Level100
storage temp.2-8C
colorlight yellow to yellow
mp300 C
formpowder
originatorGlaxoSmithKline
assay90% (NMR)
InChI1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5-,16-6-;;
solubilityDMSO: 0.2 mg/mL

Code
Description
Unit Size
List Price
Qty
D1692-25MG
Unit:25MG
List Price: £647.96
Source:List Price
ADD
Cas Number6823-69-4