MPP+ iodide has been used:• to induce oxidative stress in zebrafish embryos• for the inhibition of glutamate uptake in mitochondria of astrocytes• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.
1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson's disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.
1 g in glass bottle
100 mg in glass bottle
Solutions should be freshly prepared.