D048-100MG Display Image
D048-100MG Display Image

MPP+ iodide, >=98% (HPLC), powder

Code: D048-100MG D2-231

Application

MPP+ iodide has been used:• to induce oxidative stress in zebrafish embryos• for the inhibition of glutamate uptake in mitochondria of astrocytes• in testing cell...

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£81.18 100MG
List Price

Application

MPP+ iodide has been used:• to induce oxidative stress in zebrafish embryos• for the inhibition of glutamate uptake in mitochondria of astrocytes• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Biochem/physiol Actions

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Caution

Photosensitive.

General description

1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson's disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Packaging

1 g in glass bottle

100 mg in glass bottle

Preparation Note

Solutions should be freshly prepared.

solubilityH2O: 10 mg/mL, clear
SMILES string[I-].C[n+]1ccc(cc1)-c2ccccc2
colorwhite to beige
formpowder
assay98% (HPLC)
storage conditiondesiccated
InChI1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI keyRFDFRDXIIKROAI-UHFFFAOYSA-M
Quality Level100

Code
Description
Unit Size
List Price
Qty
D048-1G
Unit:1G
List Price: £248.89
Source:List Price
ADD
Cas Number36913-39-0
Hazard Class6.1
Un Number6.1
Pack Group2