Amino Acid Sequence
Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg
Biochem/physiol Actions
Chlorotoxin(CLTX) is a peptide isolated from the venom of scorpion Leiurus quinquestriatus. It comprises three lysines at the N-terminal region and fourdisulfide bonds. It can traverse the blood-brain barrier and can associate specifically with cancer cells especially in neuroblastoma, glioma, and medulloblastoma. CLTX binds to chloride-gated channels (CLC30) and the matrix metalloproteinase-2 (MMP2) in glioma cells. It is exploited in the imaging probe preparations for aiding non-cancer and cancer cell differentiation.
Potent blocker of small-conductance Cl- channels.
Features and Benefits
This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This product has met the following criteria: