Application

Carboplatin has been used:in chemotherapy-induced thrombocytopenia mouse model and treatmentto induce cell death in a large subset of colorectal cancer cellsin the evaluation of cell proliferation and chemosensitivityas a positive control for suppressed cell growth

Biochem/physiol Actions

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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General description

Carboplatin is used to treat testicular, ovarian and breast cancer.

Packaging

100, 250 mg in glass bottle