Analysis Note
C7 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.
Application
Complement C7 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). C7 deficiencies in patients with meningococcal meningitis have shown a mutation which results in an 11 bp deletion in exon 6 resulting in a premature stop codon. Additionally, research has suggested that screening of patients with systemic neisserial infection by CH50 or the APH-50 assay can reveal a C7 deficiency.
Physical form
Supplied as a solution in PBS, pH 7.4
This product has met the following criteria: