Application

BL-1249 has been used: as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissuesas a TWIK related potassium channel(TREK2) modulator and in U-2 OS osteosarcoma cell lineas a TREK1 and TREK2 activator in mice.

Biochem/physiol Actions

BL-1249 is a putative activator of potassium TREK-1 channel.

BL-1249 also activates TWIK related potassium channel 2(TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

Packaging

10, 50 mg in glass bottle