Amino Acid Sequence
Val-Pro-Met-Leu-Lys
Biochem/physiol Actions
Bax-mediated apoptosis inhibitor; membrane permeable pentapeptide based on the Ku70-Bax inhibiting domain.
BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug.
Other Notes
Lyophilized from 0.1% TFA in H2O
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