Application

Rabbit Anti-CBX8 antibody is suitable for western blot applications at a concentration of 2.5 µg/ml.

Biochem/physiol Actions

CBX8 is one of the proteins homolog to the Polycomb group (PcG) proteins. They assemble to form large multiprotein complexes involved in gene silencing. Evidence suggests that PcG complexes are heterogeneous with respect to both protein composition and specific function.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

CBX8 is a polycomb group protein that associates with TIP60 and MLL-AF9. It also forms a part of the PRC1 complexes. It regulates fibroblast proliferation and cell survival. Studies have reported that CBX8 is required for MLL-AF9-induced transcription and leukemogenesis.Rabbit Anti-CBX8 antibody recognizes canine, bovine, human, mouse, rat, and zebrafish CBX8.

Immunogen

Synthetic peptide directed towards the C terminal region of human CBX8

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: ARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR