Application

Use Anti-CFP1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect CFP1 also known as CXXC finger 1 (PHD domain), cpG-binding protein.

General description

CXXC finger protein 1 (CFP1) is part of the Setd1A and Setd1B methyltransferase compounds. Research shows that CFP1 also interacts with the cytosine methylation mechanism. CFP1 is necessary for development of mammals and is a key regulator of chromatin structure. Embryonic stem cells that are missing CFP1 are more susceptible to DNA-damaging agents and tend to build up more DNA damage. CFP1 has been shown to also be a regulator of DNA repair.

Immunogen

GST-tagged recombinant protein corresponding to human CFP1.

Quality

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1:1,000 dilution of this antibody detected CFP1 on 10 µg of HeLa nuclear extract.

Target description

~78 kDa observed. A cross-reacting band observed at ~110 kDa