93750-250MG Display Image

(+)-Tubocurarine chloride pentahydrate, >=97.0% (TLC)

Code: 93750-250MG D2-231

Application

(+)-Tubocurarine chloride pentahydrate has been used:as an acetylcholine receptor antagonist in synapse blocking experiment to study its effect on neuromuscular j...


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£111.00 250MG
£133.20 inc. VAT
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Application

(+)-Tubocurarine chloride pentahydrate has been used:as an acetylcholine receptor antagonist in synapse blocking experiment to study its effect on neuromuscular junction formation (NMJ) formation in a co-culture system of human skeletal muscles and human stem cell-derived motoneuronsto induce paralysis in zebrafish larvae to study whole-brain imaging of seizures by two-photon light-sheet microscopyto block NMJ to study its role in myotube contraction

Biochem/physiol Actions

(+)-Tubocurarine chloride pentahydrate serves as a neuromuscular blocker.

Classical competitive antagonist of the nicotinic acetylcholine receptor. Structure-activity relationships and conformational studies for tubocurarine binding at the nicotinic AChR.

Packaging

1 g in poly tube

250 mg in poly bottle

assay≥97.0% (TLC)
biological sourceplant
formpowder
Gene Informationhuman ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)
impurities~12% water
InChI keyWMIZITXEJNQAQK-GGDSLZADSA-N
InChI1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1
mp275-280 °C (dec.) (lit.)
optical activity[α]20/D +195±5°, c = 0.5% in H2O
Quality Level200
SMILES string[Cl-].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
93750-1G
(+)-Tubocurarine chloride pentahydrate, >=97.0% (TLC)

Unit:1G
List Price: £354.00
Source:List Price
ADD
Cas Number6989-98-6
Hazard Class6.1
Un Number1544
Pack GroupIII
This product has met the following criteria: