Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
General description
A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.Janis, R., et al. 1987. Adv. Drug Res.16, 309.
Packaging
100 mg in Alu drum
Warning
Toxicity: Toxic (F)
This product has met the following criteria: