Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 4.4 µM in suppressing glibenclamide-sensitive K+-currents

Product does not compete with ATP.

Non-selective MAO-A/B inhibitor.

General description

A non-specific phospholipase A₂ (PLA₂) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K⁺-currents (IC₅₀ = 4.4 µM). Also inhibits monoamine oxidase (MAO).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther.262, 1161.Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev.21, 33.Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 714.

Packaging

100 mg in Plastic ampoule

Reconstitution

Stock solutions are stable for up to 60 h at 20°C.

Warning

Toxicity: Harmful (C)