Biochem/physiol Actions
Cell permeable: no
Primary TargetOpioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
Reversible: no
Product does not compete with ATP.
General description
Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity at the µ, δ, or κ opioid receptors; however, nanomolar concentrations of Nociceptin inhibit, forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Madeddu, P., et al. 1999. Hypertension 33, 914.Sandin, J., et al. 1999. NeuroReport 10, 71.Meunier, J., et al. 1995. Nature 377, 532.Reinscheid, R.K., et al. 1995. Science 270, 792.
Packaging
1 mg in Plastic ampoule
Sequence
H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria: