Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetA utility carrier of nitric oxide

General description

A utility carrier of nitric oxide. Breaks down to produce nitric oxide and a glutathione radical at pH 7.4. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sandau, K., et al. 1996. Cell Signal.8, 173.Askew, S.C. 1995. Bioorg. Med. Chem.3, 1.Fehsel, K., et al. 1995. J. Immunol.155, 2858.de Belder, A.J., et al. 1994. Cardiovasc. Res.28, 691.Sexton, D.J., et al. 1994. Photochem. Photobiol.59, 463.Singh, R.J., et al. 1994. FEBS Lett. 360, 47.Merryman, P.F., et al. 1993. Arthritis Rheum.36, 1414.Park, J.W., et al. 1993. Biochem. Mol. Biol. Int.30, 885.Radomski, M.W., et al. 1992. Br. J. Pharmacol.107, 745.

Packaging

1 set in Glass bottle

Packaged under inert gas

50 mg in Plastic ampoule

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C or for up to 2 h at 4°C.

Reconstitute in cold distilled H₂O (4°C) free of divalent cations other than Ca²⁺.

Warning

Toxicity: Standard Handling (A)