Application

Reagent for the introduction of the Boc protecting group.

Di-tert-butyl dicarbonate (Boc₂O) has been used in the synthesis of:An azobenzene amino acid(aa).N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-BOC-MDMA) from MDMA.It can also be used as a reagent:To introduce acid-labile Boc-protecting group in amino acids, peptides, and proteins. To prepare styrene derivatives by Heck olefination of aromatic carboxylic acids in the presence of a Pd catalyst. To synthesize oxazolidin-2-ones and imidazolidin-2-ones by isocyanation of 1,2-aminoalcohols and 1,2-diamines using DMAP as a catalyst. In the preparation of N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-Boc-MDMA) from MDMA.For the conversion of amines to corresponding isocyanates, carbamates, and urea derivatives.In the N-BOC-ylation of amides.In the N-BOC-ylation of sensitive compounds under non-aqueous conditions.

General description

Di-tert-butyl dicarbonate (Boc₂O) is a reagent mainly used for the introduction of the Boc protecting group to amine functionalities. It is also used as a dehydrating agent in some organic reactions, particularly with carboxylic acids, certain hydroxyl groups, or with primary nitroalkanes.

Packaging

25, 100, 500 g in poly bottle

Warning

Hydrolyzes to t-butanol and CO₂; causes internal pressure in bottle if exposed to moisture.