Biochem/physiol Actions

Target IC₅₀: 3.7 µM against 5-lipoxygenase

Reversible: no

Product does not compete with ATP.

Primary Target5-lipoxygenase

Cell permeable: yes

General description

A natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A cell-permeable, selective, non-competitive inhibitor of 5-lipoxygenase (ID₅₀ = 3.7 µM). Inhibits Cu²⁺-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.

A cell-permeable natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A selective, non-competitive inhibitor of 5-lipoxygenase (ID₅₀ = 3.7 µM). Inhibits Cu²⁺-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An effective irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yamanaka, N., et al. 1997. FEBS Lett.405, 186.Chan, W.S., et al. 1995. Anticancer Res.15, 703.Ploemen, J.H., et al. 1993. Food Chem. Toxicol.31, 475.Koshihara, Y., et al. 1984. Biochim. Biophys. Acta792, 92.

Packaging

Packaged under inert gas

500 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)