Biochem/physiol Actions

Cell permeable: no

Primary TargetOpioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)

Reversible: no

Product does not compete with ATP.

General description

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity at the µ, δ, or κ opioid receptors; however, nanomolar concentrations of Nociceptin inhibit, forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Madeddu, P., et al. 1999. Hypertension 33, 914.Sandin, J., et al. 1999. NeuroReport 10, 71.Meunier, J., et al. 1995. Nature 377, 532.Reinscheid, R.K., et al. 1995. Science 270, 792.

Packaging

1 mg in Plastic ampoule

Sequence

H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH

Warning

Toxicity: Standard Handling (A)