D2141-25MG Display Image
D2141-25MG Display Image

6-Diazo-5-oxo-L-norleucine, crystalline

Code: D2141-25MG D2-231

Application

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

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£109.00 25MG
List Price

Application

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

Biochem/physiol Actions

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.

General description

Chemical structure: amino acid derivatives

application(s)ligand binding assay: suitable
antibiotic activity spectrumneoplastics
Quality Level200
SMILES stringN[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
InChI1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
Mode of actionenzyme | inhibits
colorlight yellow
formcrystalline
assay95% (TLC)
mp145 C
InChI keyYCWQAMGASJSUIP-YFKPBYRVSA-N
storage temp.20C

Code
Description
Unit Size
List Price
Qty
D2141-5MG
Unit:5MG
List Price: £31.30
Source:List Price
ADD
Cas Number157-03-9
Hazard Class6.1
Un Number6.1
Pack Group3