D2521-1G Display Image
D2521-1G Display Image

(+)-cis-Diltiazem hydrochloride, >=99% (HPLC)

Code: D2521-1G D2-231

Application

(+)-cis-Diltiazem hydrochloride has been used:• to study its effects on diffusion and release in monolithic dispersion matrix(26)• to study its neuroprotective ef...

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£93.36 1G
List Price

Application

(+)-cis-Diltiazem hydrochloride has been used:• to study its effects on diffusion and release in monolithic dispersion matrix(26)• to study its neuroprotective effects in retinitis pigmentosa (RP) models(27)• as an antagonist against the Cav1.2 L-type calcium channels (LTCCs)(28)

Biochem/physiol Actions

Blocks slow, or L-type Ca2+ channels; regulates Ca2+ release from intracellular stores in neutrophils; stimulates 1,4-dihydropyridine binding to Ca2+ channels; coronary vasodilator.

Features and Benefits

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Calcium Channels and Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Diltiazem hydrochloride is used to treat cardiovascular diseases, such as angina and hypertension. It acts as an inhibitor to cytochrome P450 3A (CYP3A). Diltiazem might be associated with maculopapular rashes, urticaria and pruritus.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

1, 5, 10 g in poly bottle

SMILES stringCl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
Quality Level200
storage temp.2-8C
assay99% (HPLC)
InChI keyHDRXZJPWHTXQRI-BHDTVMLSSA-N
originatorValeant
InChI1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

Code
Description
Unit Size
List Price
Qty
D2521-10G
Unit:10G
List Price: £643.76
Source:List Price
ADD
D2521-5G
Unit:5G
List Price: £354.96
Source:List Price
ADD
Cas Number33286-22-5